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InDroso functional genomics

CRISPR/Cas9 transgenic flies (Drosophila)

About us

Our team

inDroso is building a reliable service platform producing custom CRISPR genome edited flies

Spin-off of the Institute of Genetics and Development of Rennes (IGDR), inDroso wants to become your first choice for Drosophila genome editing services. InDroso handles the custom engineering of your fly lines in an all-inclusive fashion from the design of the constructs to the delivery of the stabilized fly lines.
Our genome editing service provides excellent speed of delivery of CRISPR flies and relies on the latest advances in the field so you can quickly start your work with optimal tools.

Christine Le Borgne

Christine Le Borgne, executive MBA - Business Manager

Christine Le Borgne has a degree in Business Administration from the Business School of Management Audencia in Nantes.
Christine has 20 years of experience in Sales and Marketing of breakthrough technological solutions in the Life Science Industry.
As the Business Manager of inDroso she wants to provide the scientific community with quality research tools: CRISPR transgenic flies.
She ensures that inDroso’s all-inclusive service is the logical solution for the laboratories using Drosophila as a model system to other alternatives and guarantees that inDroso is a valuable resource to support the productivity of your research and the performance of your laboratory.

Roland Le Borgne

Dr. Roland Le Borgne, Group Leader IGDR - Scientific Director

After completion of his PhD in Cell Biology at the European Molecular Biology Laboratory in Heidelberg and his post-doctoral training at the Pasteur Institute in Lille, Dr. Roland Le Borgne joined the laboratory of Dr. F. Schweisguth at the Ecole Normale Supérieure in Paris to enter the fascinating world of Drosophila genetics.
Since 2006 he has been a CNRS research director and Group Leader at the Institute of Genetics and Development of Rennes.
Dr. Le Borgne’s laboratory uses of Drosophila melanogaster as a model system to study asymmetric cell division: how a cell produces two daughter cells with different identities and how defects in this asymmetry contribute to diseases are the fundamental questions addressed. To reach these goals, his laboratory is employing innovative approaches such as state-of-the-art light and electron microscopy, biophysics, combined with advanced fly genetics including CRISPR/cas9 mediated genome editing.
Roland is a founder of inDroso and his work has made it possible for Drosophila laboratories to outsource their production of CRISPR flies as a competitive alternative to producing them by themselves.

Aslak Rouaze

Aslak Rouaze, Research Engineer

After a MSc degree in Cellular and Molecular Life Sciences at the University of Rennes, Aslak pursued a MSc degree in Genetics, Immunology and Cancer at the University of Caen. During his MSc, he spent 6 months in the laboratory of Michael Lisby at the Biocenter Copenhagen, biology department in Denmark and 6 months in the laboratory of Evi Soutoglou, at the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France. Aslak joined inDroso in 2015. His motivation: keep pace with the continuous technological evolution of genome editing techniques and become a valuable external resource for your laboratory.

Céline Bruelle

Céline Bruelle, Research Engineer

Céline did her PhD at the Institut de Biologie Intégrative et des Systèmes (IBIS) under the supervision of Professor Michel Vincent at Laval University, Quebec, where she studied the role of p54nrb. Céline continued her postdoctoral studies in the laboratory of Professor Dan Lindholm at the Biomedical Institute of the University of Helsinki in Finland. She has involved in the understanding of the molecular mechanisms underlying neurodegenerative diseases. With 10 years of research in molecular and cellular biology, she has acquired solid expertise and technical skills in genetic engineering and molecular biology to successfully carry out your projects at the highest level. Her aim: to ensure the highest quality of service and production procedures to provide reliable tools to Drosophila laboratories interested in acquiring flies generated using the latest CRISPR methodologies to support their science.

Mathieu Jousseaume

Matthieu Jousseaume, Study Engineer

Matthieu hold a MSc degree in Cellular and Molecular Life Sciences from the University of Rennes. During his master's degree, he spent 6 months in Professor Luc Paillard's laboratory, "Genetic Expression and Development" at Institut de Génétique et de Développement de Rennes.. Matthieu developed his skills as molecular biologist using the CRISPR/Cas9 to engineer animal models. He joined inDroso in mid-2017. His objective: to contribute to the establishment of a state-of-the-art service platform with unique expertise in the execution of the CRISPR approach for the edition of the Drosophila genome.

The laboratory is uniquely equipped to produce custom genome edited CRISPR flies.
Below few photographs of the equipment illustrating the procedure followed for the generation of genome engineered Drosophila melanogaster.

Molecular cloning of guide RNA and donor plasmids
Molecular cloning of guide RNA and donor plasmids
The microinjection device used to inject Cas9 embryos
The microinjection device used to inject Cas9 embryos
inDroso's fly facility
inDroso's fly facility
inDroso’s fly incubator: the place of birth of your next CRISPR flies?
inDroso’s fly incubator: the place of birth of your next CRISPR flies?
InDroso's microscope for the screening of fluorescent selection marker.
InDroso's microscope for the screening of fluorescent selection marker.